Leadership team

Orchard’s management team has extensive expertise in R&D, manufacturing and commercialization of rare diseases and gene therapy.

Mark Rothera

Mark Rothera

Mark Rothera

President & Chief Executive Officer

Mark brings 28 years of experience in the bio-pharmaceutical industry including driving the transition of multiple emerging biotechnology companies from R&D stage to commercialisation. During his career, he has focused on bringing novel therapies to market for patients with rare diseases, and has launched seven orphan drugs. 

Prior to Orchard Therapeutics, Mark served as Chief Commercial Officer of PTC Therapeutics (“PTC”) where he helped transition the company from a privately funded, US-based R&D biotech to a public, commercial stage company with a 47 country commercialisation footprint. This he achieved by building a global commercialisation capability and successfully launching two rare disease therapies.

Prior to joining PTC, Mark served as Global President of Aegerion Pharmaceuticals Inc. and Head EMEA region at Shire Human Genetics. Mark received an M.A. in Natural Sciences from Cambridge University and an MBA from INSEAD.

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John Cerio

John Cerio

John Cerio

SVP & Global Head of Human Resources

John brings over 25 years of HR leadership experience in the pharmaceutical and biotech industry building high growth, high performance, mission driven and entrepreneurial companies.

Until recently John served as Vice President of Human Resources and Administration for Agenus where he led the HR function through periods of rapid growth, transformation and global expansion including the acquisition and integration of 4-antibody AG and the recruiting and on-boarding of over 150 R&D staff, responsible for creating and advancing an Immuno-oncology portfolio of over a dozen clinical candidates including 4 that are currently in phase 2. Prior to Agenus, he was Vice President of Global HR for PerkinElmer Life Sciences during which time the company more than doubled in size and annual sales. Earlier in his career, John spent nearly 10 years with Bristol-Myers Squibb company in a series of HR leadership roles with increasing responsibilities ranging from Director of HR for Corporate Staff to Head of HR for their Oncology and Immunology division.

John earned his B.S. in Industrial and Labor Relations from Cornell and his M.A. in Organizational Psychology from Columbia. He also completed the Global Leadership Development Programme at the London Business School.

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Stewart Craig

Stewart Craig

Stewart Craig

PhD – Chief Manufacturing Officer

Stewart has more than 30 years of experience in development, cGMP manufacturing, quality systems and regulatory affairs for complex biologicals.

For the past 20 years he has held executive level positions designing, implementing and operating the CMC and GMP manufacturing infrastructure for various public and private cell and gene therapy companies, including Sangamo BioSciences, StemCells Inc., Progenitor Cell Therapy, Xcyte Therapies, Osiris Therapeutics, and SyStemix, Inc.

He has successfully led development, manufacture and clinical delivery of HSPCs, MSCs, NSCs, activated T cells, gene-modified T cells & gene-modified HSPCs. He also has extensive experience in regulatory affairs with successful cell and gene therapy submissions in US, Canada and Europe.

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Anne Dupraz-Poiseau

Anne Dupraz-Poiseau

Anne Dupraz-Poiseau

PhD – Chief Regulatory Officer

Anne brings to Orchard Therapeutics more than 20 years of experience of tackling R&D, clinical and regulatory challenges for global development within medtech and biotech companies.

Prior to joining Orchard Therapeutics, she was Executive Vice President at VCLS (Voisin Consulting Life Sciences), where she was actively involved in the design, preparation and management of high number of successful regulatory submissions at all stages of product development. She managed over 50 different cell, tissue and gene based therapies development programs over the last 3 years. She established strong communication links with Regulators, including the Food and Drug Administration (FDA) in the United States and the European Medicines Agency (EMA).  

Anne possesses extensive expertise in human Cell, Tissue and Gene Therapies, so called Advanced Therapy Medicinal Products (ATmPs) in Europe. Bringing together scientific and regulatory expertise in this area, she actively participated in the elaboration of the European ATmPs’ Regulation through Industry Associations and worked closely with the  European Medicines Agency (EMA) on related guidelines.

Anne began her career as a Research & Development Project Manager for Medtronic Sofamor-Danek after earning a joint PhD degree from the University of Dental Surgery in Nantes, France, the Free University of Berlin, Germany and the University of Medicine of Leiden, Netherlands, working on the development and evaluation of drug-device combination products aimed at bone substitution. Before joining VCLS, Anne co-founded the regulatory consulting firm Meditest International.  

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Bobby Gaspar

Bobby Gaspar

Bobby Gaspar

MD – Chief Scientific Officer

Bobby is Professor of paediatrics and immunology at the UCL Institute of Child Health and Honorary Consultant in paediatric immunology at Great Ormond Street Hospital, London.

He has a special interest in the treatment of severe primary immune deficiencies, including bone marrow transplantation, gene and cell therapy. He has led multiple clinical trials that have shown that gene therapy can successfully correct the genetic defect in immune deficiencies.

Bobby is currently leading UK and European-wide initiatives for newborn screening in severe combined immune deficiency. He is Director of the Centre for Research in Rare Diseases in Children (CRRDC), a new academic and clinical facility that will open at Great Ormond Street in 2018.

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John Ilett

John Ilett

John Ilett

General Counsel & Company Secretary

John brings broad expertise in corporate, commercial and IP law. He has extensive experience in legal, compliance and corporate secretarial roles in international biopharmaceutical and life sciences companies. He also brings commercial and biotech intellectual property experience.

Prior to joining Orchard, John was a non-executive director at Oxular Limited and group general counsel & company secretary at Consort Medical plc. He held senior legal affairs roles at several companies operating in the rare disease space including Synageva, BioMarin and Oxford GlycoSciences.

John is a qualified solicitor. He received his Bachelor of Law degree in Business Law from City of London, his postgraduate diploma in EC Competition Law from King's College, London and a postgraduate diploma in Intellectual Property Law from Queen Mary University of London.

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Nicolas Koebel

Nicolas Koebel

Nicolas Koebel

Chief of Staff & Head of Program Management and Corporate Communications

Nicolas is a co-founder of Orchard Therapeutics and joined the company in October 2015, as the first founding member of Orchard's management team. Nicolas brings extensive experience in Commercial and Market Access Strategy and Business Operations.

Prior to joining Orchard Therapeutics, he held positions of increasing responsibility in GSK's R&D and Commercial operations (2005–2015). Nicolas was responsible for commercialization plans for GSK's development programs in Respiratory, Dermatology and Regenerative Medicine. He played a key role in Business Development activities resulting in the acquisition of Stiefel Laboratories (2009) and the strategic alliance with TIGET (the Telethon Institute of Gene Therapy) to develop autologous gene therapy medicines (2010). In 2011, Nicolas was appointed Global Commercial Lead to GSK's Rare Diseases Unit, to oversee the commercialization of GSK's programme of autologous ex-vivo gene therapies. Prior to working with GSK, he has advised clients in the Fine Chemicals and Resources industries in operational effectiveness projects (1999–2004).

Nicolas has a Master's Degree of Political Sciences from the Institute of Political Sciences in Strasbourg (France) and a Degree in Finance and Economics from the Graduate Institute of International Studies in Geneva (Switzerland).

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Adrien Lemoine

Adrien Lemoine

Adrien Lemoine

SVP Business Development & Alliance Management

Adrien brings to Orchard Therapeutics more than 15 years of experience growing pharma and biotech businesses via in- and out-licensing, M&A and portfolio development.

Prior to joining Orchard, Adrien was Executive Director, Corporate Strategy and Development at AstraZeneca where he was leading M&A activities as well as successful out-licensing and new companies spin-off projects. He was a member of the Board of Directors of Corvidia Therapeutics.

Prior to AstraZeneca, Adrien spent 9 years at GSK and his most recent experience was Strategy & Operations Director in the Rare Diseases Unit, where he worked in particular on the in-licensing of the TIGET (the Telethon Institute of Gene Therapy) autologous gene therapy portfolio and other successful business development activities. He was a member of the Advisory Committee for Kurma BioFund II, a venture capital fund with a special focus on rare diseases.

His experience at GSK also encompasses European and global roles of increasing seniority in R&D portfolio strategy and commercial analysis. He started his career as a strategy consultant at Alcimed (Paris, France), supporting the development of biotechnology start-up companies. Adrien holds an Engineering Degree from Supélec (Paris, France) and a MSc in Engineering and Physical Science in Medicine from Imperial College (London, UK).

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Jason Meyenburg

Jason Meyenburg

Jason Meyenburg

Chief Commercial Officer

Jason brings extensive global commercialization experience to Orchard including the launch of multiple therapies for ultra-rare life-threatening diseases, new market entry strategies, market access and organizational development. He led the global commercialization of gene therapies for primary immune deficiencies and inherited metabolic disorders.

Prior to joining Orchard, Jason served as chief commercial officer at Sucampo Pharmaceuticals, Inc. and Vtesse. He also led commercial operations at Alexion in the U.S. and Latin America in the haematology, nephrology and metabolic business units, and held commercial leadership roles expanding access to the company's products in Europe, the Middle-East, Africa and Japan.

Jason holds a Bachelor of Science in Biochemistry from the University of Maryland and a Master of Business Administration from Duke University's Fuqua School of Business.

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Andrea Spezzi

Andrea Spezzi

Andrea Spezzi

Chief Medical Officer

Andrea is a co-founder of Orchard Therapeutics and brings to the company extensive experience and expertise in the development and execution of all aspects of clinical development and particularly in paediatric rare diseases.

Prior to joining Orchard Therapeutics, Andrea served as VP and Medicine Development Leader at GSK Rare Diseases Unit. Previous to joining the GSK Rare Diseases Unit, Andrea was Senior Medical Director at the Immune Inflammation Discovery Performance Unit. Before GSK, Andrea was Global Medical Director R&D at Takeda in the metabolic and cardiovascular area and in charge of the paediatric developments for Takeda Europe R&D. Before that, she worked as Research Physician at Hammersmith Medicines Research. Before moving to the pharmaceutical industry Andrea practiced as a paediatrician for 12 years in Argentina, Spain and UK.

Andrea obtained her medical degree from the University of Buenos Aires (UBA) and completed residency in paediatrics and post graduate training in paediatric immunology at the Dr Elizalde Children's Hospital in Buenos Aires, Argentina. She obtained a Specialist in Pharmaceutical Medicine degree from University of Basel, Switzerland and she is a Fellow of the Faculty of Pharmaceutical Medicine in London, UK (FFPM).

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Frank Thomas

Frank Thomas

Frank Thomas

Chief Financial Officer and Chief Business Officer

Frank brings nearly 20 years of experience in the biopharmaceutical industry as an accomplished financial and business executive. Frank has a background developing and executing capital markets strategies for private and public companies as well as experience in operations management, and corporate and business development.

Until recently Frank served as president and chief operating officer of AMAG Pharmaceuticals where he helped develop the business from a single product company in 2011 to one with a portfolio of commercial and development-stage products that generated more than $600 million in sales in 2017. During that time, Frank raised more than $1.8 billion in new capital to support the significant growth of AMAG.

Before joining AMAG, he served as chief operating officer and chief financial officer for Molecular Biometrics, Inc. Earlier in his career, Frank also served as chief financial officer for Critical Therapeutics and Esperion Therapeutics. Each completed its initial public offering in the United States during his tenure. Frank currently serves on the board of directors of Zafgen (Nasdaq: ZFGN) and Spero Therapeutics (Nasdaq: SPRO). Frank received a Bachelor of Business Administration (BBA) from the University of Michigan, Ann Arbor.

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