Senior Research Associate, Analytical Development - Menlo Park


Menlo Park, California, United States

Analytical Operations

Reports to: Senior Scientist, Analytical Operations

Location: Menlo Park, CA

Orchard Therapeutics, Ltd. is a biotechnology company incorporated in September 2015 and dedicated to bringing transformative gene therapies to patients with serious and life-threatening rare diseases. This an exciting opportunity for a well-qualified candidate to join a rapidly growing international company focused on transforming the lives of patients through innovative gene therapies.

Job Summary

We are seeking an innovative, motivated and results-oriented candidate, who thrives on increasing levels of responsibility. You will be joining a dynamic team responsible for the development and characterization of clinical-scale manufacturing processes for therapies. The successful candidate will help to develop, optimize and qualify/validate analytical methods for the characterization, release and stability testing of lentiviral vector products and cell therapy drug product.

Job Responsibilities:

Actively contribute to successful development, qualification and execution of robust, state-of-the-art analytical methods for characterization of Lentiviral vector and cell therapy drug product manufacturing processes

Provide analytical support for clinical-scale non-GMP/GMP IND-enabling manufacturing operations, including qualification of in-process and release methods and tech transfer internally and externally in support of GMP manufacturing and release of clinical material.

Contribute to relevant and impactful innovation programs to enhance product characterization technologies.

Contribute to project technical teams to ensure effective integration at all levels. Communicate and collaborate effectively.

Demonstrate strong accountability as well as good organizational and interpersonal skills.

Details-oriented, quick learner and with hands-on

Ensure high-quality, timely documentation in laboratory notebooks and technical reports.

Present data to scientists and management in internal venues (technical and project team meetings).

Requirements

  • MS degree in Cell Biology/Biochemistry/Immunology or related field with 3+ years of experience in biotech/ biopharma industry (any experience in the development of analytical methods for the characterization of gene- or cell-based therapies would be a strong bonus).
  • The individual will work under manager supervision to plan and conduct hands-on laboratory experiments independently, and, apply advanced scientific knowledge to complete projects.
  • Broad technical proficiency in cell culture is a must. Experience in analytical procedures such as enzyme activity assay, ELISA, cell-based functional assay, FACS, qPCR assay is desirable. Experienced with viral vector transduction is a plus.
  • Flexibility in a fast-paced, changing environment; be willing to accept responsibilities outside of the initial job description
  • Experience in assay design, optimization, validation, experimental design, data analysis, and data and concept presentation
  • Handle multiple tasks efficiently, capable of critical thinking, data analysis and interpretation skill
  • Good interpersonal, verbal, and written communication skills
  • Proficiency in Microsoft Word, Excel, and PowerPoint

Benefits

The successful candidate will enjoy a competitive base salary and the opportunity to participate in incentive compensation programs, including a stock option plans. Orchard Therapeutics, Ltd. offers a comprehensive benefits program, including: medical, dental and vision care; paid vacation and holiday time; access to a voluntary 401(k). Orchard Therapeutics is an equal opportunity employer.

Notice to All Applicants: Orchard Therapeutics participates in E-Verify

Notice to RECRUITERS: All employment offers and CV’s are managed through our Human Resources Department and all candidates are presented through this avenue. Therefore, the Human Resources Department at Orchard Therapeutics requests that recruiters are not to contact Orchard Therapeutics employees directly to present candidates. Complying with this request will be a factor in determining future professional relationships with Orchard Therapeutics. Orchard Therapeutics will not accept unsolicited resumes from any source other than directly from candidates for either current or future positions. Submission of unsolicited resumes in advance of an agreement between the Human Resources Department and the recruiter does not create any implied obligation on the part of Orchard Therapeutics.