Senior Research Associate, Analytical Operations - AOQC3


Full-time

Menlo Park, California, United States

Analytical Operations

Senior Research Associate, Analytical Operations


Reports to: Senior Scientist
Location: Menlo Park, CA

The company

Orchard Therapeutics is a fully integrated commercial-stage biopharmaceutical company dedicated to transforming the lives of patients with serious and life-threatening rare disease through innovative gene therapies.

Orchard’s portfolio of autologous ex vivo gene therapies includes Strimvelis, the first autologous ex vivo gene therapy approved by the European Medicines Agency for adenosine deaminase severe combined immunodeficiency (ADA-SCID). Additional programs for neurometabolic disorders, primary immune deficiencies and hemoglobinopathies include three advanced registrational studies for metachromatic leukodystrophy (MLD), ADA-SCID and Wiskott-Aldrich syndrome (WAS), clinical programs for X-linked chronic granulomatous disease (X-CGD) and transfusion-dependent beta-thalassemia (TDBT), as well as an extensive preclinical pipeline.

Orchard currently has offices in the U.K. and the U.S., including London, San Francisco and Boston

Job Summary

We are seeking an innovative, motivated and results-oriented candidate, who thrives on increasing levels of responsibility. You will be joining a dynamic team responsible for the development and characterization of clinical-scale manufacturing processes for therapies. The successful candidate will help to develop, optimize and qualify/validate analytical methods for the characterization, release and stability testing of lentiviral vector products and cell therapy drug product.

Job Responsibilities:

  • Actively contribute to successful development, qualification and execution of robust, state-of-the-art analytical methods for characterization of Lentiviral vector and cell therapy drug product manufacturing processes.
  • Provide analytical support for clinical-scale non-GMP/GMP IND-enabling manufacturing operations, including qualification of in-process and release methods and tech transfer internally and externally in support of GMP manufacturing and release of clinical material.
  • Contribute to relevant and impactful innovation programs to enhance product characterization technologies.
  • Contribute to project technical teams to ensure effective integration at all levels. Communicate and collaborate effectively.
  • Demonstrate strong accountability as well as good organizational and interpersonal skills.
  • Details-oriented, quick learner and with hands-on
  • Ensure high-quality, timely documentation in laboratory notebooks and technical reports.
  • Present data to scientists and management in internal venues (technical and project team meetings).

Requirements

  • MS degree in Cell Biology/Biochemistry/Immunology or related field with 3+ years of experience in biotech/ biopharma industry (Experience in the development of analytical methods for the characterization of gene- or cell-based therapies would be a strong bonus). PhD degree in the same field with 0+ years of experience in the same field is also desired.
  • The individual will work under manager supervision to plan and conduct hands-on laboratory experiments independently, and, apply advanced scientific knowledge to complete projects.
  • Broad technical proficiency in cell culture is a must. Experience in analytical procedures such as enzyme activity assay, ELISA, cell-based functional assay, FACS, qPCR assay is desirable. Experience with viral vector transduction is a plus.
  • Flexibility in a fast-paced, changing environment; be willing to accept responsibilities outside of the initial job description
  • Experience in assay design, optimization, validation, experimental design, data analysis, and data and concept presentation
  • Handle multiple tasks efficiently, capable of critical thinking, data analysis and interpretation skill
  • Good interpersonal, verbal, and written communication skills
  • Proficiency in Microsoft Word, Excel, and PowerPoint

Benefits

The successful candidate will enjoy a competitive base salary and the opportunity to participate in incentive compensation programs, including a stock option plans. Orchard Therapeutics, Ltd. offers a comprehensive benefits program, including: medical, dental and vision care; paid vacation and holiday time; access to a voluntary 401(k). Orchard Therapeutics is an equal opportunity employer.


Notice to All Applicants: Orchard Therapeutics participates in E-Verify

For further information on this role do not hesitate to email HR@orchard-tx.com


RECRUITERS

All employment offers and CV’s are managed through our Human Resources Department and all candidates are presented through this avenue. Therefore, the Human Resources Department at Orchard Therapeutics requests that recruiters are not to contact Orchard Therapeutics employees directly to present candidates. Complying with this request will be a factor in determining future professional relationships with Orchard Therapeutics. Orchard Therapeutics will not accept unsolicited resumes from any source other than directly from candidates for either current or future positions. Submission of unsolicited resumes in advance of an agreement between the Human Resources Department and the recruiter does not create any implied obligation on the part of Orchard Therapeutics.